Banothile Makhubela was born in Mzinti (Mpumalanga Province, South Africa). She was awarded a Bachelor of Science degree in Chemistry and Mathematics by the University of Zululand in 2005 and obtained a BSc. Honours in Chemistry in 2006 from the University of Cape Town (UCT). In 2008 she completed an M.Sc. program by dissertation supervised by the late Prof John R. Moss and Prof Gregory S. Smith. In 2012, she was awarded a PhD by UCT for a thesis (supervised by Prof. Gregory S. Smith and Dr. Anwar M. Jardine) focused on the design, synthesis and characterization of novel platinum group metal (PGM) based organometallic complexes tethered/anchored onto macromolecules and biopolymers. Dr Makhubela was granted the UCT Science Faculty, Oppenheimer Memorial Trust and National Research Foundation (NRF) Innovation Postdoc Fellowships to undertake postdoctoral research where she studied new PGM metal-containing polymers and metallodendrimers with biomedical applications as anti-cancer agents. This work has revealed promising insights into the cytotoxic mechanism of ruthenium- and osmium–containing complexes/ macromolecules against cancer cells that will aid rational design of metallo-drugs in the future.